Edibles:
A Tasty Trip

Understanding the Power of 11-Hydroxy-THC

By Meagan Chris 

Edibles offer a unique and often potent way to experience the effects of cannabis. Unlike smoking or vaping, edibles are ingested, usually in the form of treats like candies, chocolates, or baked goods. This method of consumption leads to a different metabolic pathway, resulting in a distinct experience thanks to a powerful compound: 11-hydroxy-THC.

The Edible Experience: More Than Just a Treat

Edibles provide several advantages:

• Smoke-free option: A great alternative for those who prefer not to inhale cannabis, avoiding potential respiratory irritation or long-term lung health concerns associated with smoking.
• Long-lasting effects: Edibles typically produce effects that last longer than smoking, sometimes for several hours. This extended duration can be beneficial for managing chronic conditions or for those seeking a longer-lasting experience.
• Discreet consumption: Often easier to consume discreetly in various situations, as they don’t produce the telltale smell of smoke. This can be a significant advantage for those who need to medicate discreetly or who prefer to keep their cannabis use private.
• Potential medical benefits: May be more effective for certain medical conditions, such as nausea, chronic pain, appetite loss, and insomnia. The longer-lasting effects can be particularly helpful for managing chronic pain, allowing for sustained relief. Some find low-dose edibles more effective for anxiety than inhaled cannabis.
• Precise dosing: Commercially produced edibles often offer more precise dosing than other consumption methods, allowing users to better control their intake and manage their experience. This is particularly important for medical users who require consistent dosing.
• Variety of forms and flavors: Edibles come in a wide array of forms, from gummies and chocolates to drink mixes and beverages. This variety allows users to choose products that suit their tastes and preferences, making the experience more enjoyable. This variety can also cater to dietary restrictions, with options like vegan or gluten-free edibles available.
• Potentially stronger effects: Due to the conversion of delta-9-THC to 11-hydroxy-THC, edibles can produce a more intense psychoactive experience than smoking or vaping, which some users may prefer.

Edibles can be used for various purposes, including:

• Pain relief: Addressing chronic pain, menstrual cramps, inflammation, arthritis, and neuropathic pain. The sustained release of cannabinoids in edibles can be particularly beneficial for managing chronic pain conditions.
• Nausea and vomiting relief: Especially helpful for those undergoing chemotherapy, experiencing motion sickness, or dealing with other forms of nausea. Edibles can provide longer-lasting relief than inhaled cannabis for nausea.
• Muscle spasm relief: Beneficial for conditions like multiple sclerosis, cerebral palsy, and other conditions characterized by muscle spasticity. The relaxing effects of cannabinoids can help to reduce muscle tension and spasms.
• Anxiety and stress relief: Lower doses can provide a calming effect, helping to manage anxiety disorders, social anxiety, and general stress. However, it’s important to note that higher doses can sometimes exacerbate anxiety in some individuals.
• Appetite improvement: Helpful for individuals struggling with eating disorders or appetite loss due to medical treatments like chemotherapy. Cannabis can stimulate appetite and help to increase food intake.
• Sleep aid: Some edibles, particularly those with higher CBN content, can promote relaxation and improve sleep quality. They may be helpful for individuals with insomnia or other sleep disorders.
• Management of specific medical conditions: Some research suggests that edibles high in CBD may be beneficial for managing symptoms associated with conditions like inflammatory bowel disease (IBD), glaucoma, and certain neurological disorders. However, more research is needed in these areas.
• Recreational use: Many individuals use edibles for recreational purposes, seeking the euphoric and relaxing effects of THC. When used recreationally, it’s important to consume responsibly and be mindful of dosage.

The Magic of Metabolism: 11-Hydroxy-THC

The key to understanding the edible experience lies in the journey of THC through your body. When you smoke or vape cannabis, delta-9-THC enters your bloodstream directly and travels to your brain. Edibles, however, take a different route. After ingestion, they are processed by your liver, which transforms the delta-9-THC into 11-hydroxy-THC.

This transformation is crucial because 11-hydroxy-THC is significantly more potent than delta-9-THC and crosses the blood-brain barrier more easily. This results in a stronger and longer-lasting high.

Why 11-Hydroxy-THC Matters

• Increased Potency: 11-hydroxy-THC binds more effectively to the cannabinoid receptors in your brain, leading to a more intense psychoactive effect.
• Longer Duration: The liver processes THC into 11-hydroxy-THC gradually, causing the high from edibles to come on slower but last much longer.
• Unpredictability: Factors like metabolism, genetics, stomach contents, and the specific edible product influence how your liver metabolizes THC. This makes dosing edibles more challenging and can lead to unexpected experiences, particularly for new users.

Edible Consumption Tips: Start Low and Go Slow

Because of the unique properties of 11-hydroxy-THC, responsible consumption is essential:

• Start low, go slow: Begin with a very small dose (around 5mg of THC for new users) and wait at least 45 minutes before consuming more. It’s much easier to add more than to counteract the effects of a large dose.
• Be patient: Edibles take time to work. Don’t assume “it’s not working” and consume more too quickly. The effects can be delayed.
• Hydrate: Stay well-hydrated throughout the experience.
• Consider your environment: Choose a comfortable and relaxing setting to enjoy your edibles.
• Know your source: Purchase edibles from reputable dispensaries or producers to ensure accurate labeling and consistent dosing. Homemade edibles can be particularly difficult to dose accurately.
• Understand your body: Everyone metabolizes THC (And other cannabinoids) differently. Pay attention to how your body reacts and adjust your dosage accordingly.

By understanding the science behind edibles, particularly the role of 11-hydroxy-THC, and following these consumption tips, you can have a more informed and enjoyable experience.

Meagan Chris
Co-Owner of CannaChris Consulting,

Meagan Chris is a passionate advocate for elevating the cannabis industry. With over 6 years of experience, including leadership roles and diverse consulting projects, Meagan specializes in cannabis education & training, business consulting, product development, and patient advocacy. She’s dedicated to improving patient outcomes and driving business success within the cannabis sector.